Scivation Amp/Sesamin, Stack

Sesamin is a lignan isolated from sesame seeds. A lignan is a molecule that combines with another entity acting as an “activator.” In the case of sesamin, it binds to and activates a receptor called Peroxisome Proliferator-Activator Receptor Alpha (PPARalpha). Sesamin has been shown to be a potent PPARalpha activator [1].

The PPAR receptor family is divided into three subgroups: alpha, beta/delta, and gamma. PPARalpha is highly expressed in muscle, the liver, kidneys, and heart and is involved in the regulation of lipid metabolism, specifically the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis. Activation of PPARalpha increases gene expression of the fatty acid oxidation enzymes and decreases gene expression of lipogenic enzymes.

Of vital important, Sesamin increases the expression of the mitochondrial enzyme carnitine palmitoyl transferase (CPT), among other enzymes [2]. CPT, the rate-limiting enzyme in beta-oxidation of fatty acids in skeletal muscle and liver cell mitochondria, is found on the outer membrane of mitochondria and carries fatty acids across the membrane into the mitochondria by binding to them. Increasing the expression of CPT, along with other enzymes involved in beta-oxidation, will allow more fatty acids to be transported into the mitochondria where they can be oxidized.

In addition to increasing the oxidation of fat, Sesamin supplementation has also been shown to decrease lipogenesis (fat storage) by decreasing lipogenic enzymes in the liver. Sesamin has been shown to decrease lipogenic the gene expression of sterol regulatory element binding protein-1 (SREBP-1), acetyl-CoA carboxylase, and fatty acid synthase, among other lipogenic enzymes [3], which means less fat is esterifized in the liver and therefore less fat is stored in adipose tissue (fat cells). So Sesamin works in two ways to make you lean (and keep you lean): increasing fat oxidation and decreasing fat storage.

Amped metabolisms are made not born. And we’ve created a monster.

Introducing ErgoLean™ AMP from ErgoPharm. This monstrous breakthrough represents a culmination of years of research, trial and error. Since the ephedra-free products have all fallen short of providing the buzz that drove the true frenzy associated with ephedra-based fat burners, Patrick Arnold and ErgoPharm set out to deliver where others failed. The effects of AMP upon endurance, strength, and perceived exertion are astounding.

The Birth of Geranamine™

ErgoLean AMP contains the most exciting fat loss ingredient available since ephedrine. The centerpiece of ErgoLean AMP is Geranamine™. An ErgoPharm exclusive, Geranamine is an adrenaline-like compound with energy producing effects that have to be felt to be believed. Destined to be the true ephedra replacement, Geranamine also affects biological pathways known to produce potent appetite suppressant and thermogenic actions, while also acting as a powerful pre-workout energy booster.

Thermo-Stimulant Gadgetry

ErgoLean AMP also contains Chocamine™, a powerful stimulant, possessing hunger-demolishing properties. Chocamine contains several natural ingredients to both thwart hunger and stimulate the central nervous system. The methylaxanthines in Chocamine serve to potentiate the adrenaline-like activity of Geranamine via downstream messenger chemical modulations.

Caffeine is well established as a fat-burning gadget. Its presence in ErgoLean AMP, coupled with Chocamine, helps to ensure that any negative energy balance induced by the dieting is fed by stored bodyfat and not precious muscle.

No more puny ephedra-free products to serve rations of continual disappointment. ErgoLean AMP is a creature created to intimidate bodyfat, to pour electricity into your brain and to light a fire under your ass.

The Monster has been created and there is nowhere to hide.